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DTSTART:20250330T010000
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DTSTART;TZID=Europe/Ljubljana:20251127T110000
DTEND;TZID=Europe/Ljubljana:20251127T120000
DTSTAMP:20260422T093215
CREATED:20251110T154305Z
LAST-MODIFIED:20251127T104230Z
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SUMMARY:Patrick Stengel: Nuclear recoil detection with color centers in bulk lithium fluoride
DESCRIPTION:We present initial results on nuclear recoil detection based on the fluorescence of color centers created by nuclear recoils in lithium fluoride. We use gamma rays\, fast and thermal neutrons\, and study the difference in responses they induce\, showing that this type of detector is rather insensitive to gamma rays. We use light-sheet fluorescence microscopy to image nuclear recoil tracks from fast and thermal neutron interactions deep inside a cubic-centimeter sized crystal and demonstrate automated feature extraction in three dimensions using machine learning tools. The number\, size\, and topology of the events agree with expectations based on simulations with TRIM. These results constitute the first step towards 10-1000g scale detectors with single-event sensitivity for applications such as the detection of dark matter particles\, reactor neutrinos\, and neutrons.\nhttps://indico.ijs.si/event/3293/
URL:https://web-f1.ijs.si/event/patrick-stengel/
LOCATION:A/1-106 – Seminarska soba fizike (F5)
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DTSTART;TZID=Europe/Ljubljana:20251127T141500
DTEND;TZID=Europe/Ljubljana:20251127T151500
DTSTAMP:20260422T093215
CREATED:20251103T142728Z
LAST-MODIFIED:20251112T165846Z
UID:77716-1764252900-1764256500@web-f1.ijs.si
SUMMARY:Miroslav Vořechovský\, "Model for Mechanistic Coupling of Patterning and Proliferation in Organoids by a 3D Vertex Model"
DESCRIPTION:A three-dimensional computational model inspired by the work Okuda and his collaborators \, is developed to reveal the interaction between patterning and proliferation in epithelial tissue. The geometrical representation is based on Voronoi cells representing individual cells and differentiating the lateral\, apical an basal cell faces. The viscous-damped system of forces controlling the shape of the multicellular tissue is derived from a potential featuring both volumetric and surface terms. Equipped with the cell rearrangements via cell-neighbor exchanges\, the model allows for cell division and splitting while following the cell cycles.Fig. 1 Cell division during pattern-driven growth from initial single-layered spherical organoid.Pattering is controlled by the interplay of two morphogens (activator and inhibitor) in a reaction-diffusion system . The formation of patterns controls the cell proliferation in which the local concentration of activator which plays a role of a mitogen. The cell growth rate is modelled via Hill equation in which the exponent plays a central role in the presented coupling between patterning and proliferation.The developed model is used to decipher the diverse roles of ERK and Akt signaling in organoid morphogenesis by matching the laboratory data. In our computational model of multicellular organoid growth\, we have identified a feedback loop between the formation of patterns\, influencing the rate of cell proliferation and consequently the tissue mass increase. This feedback loop critically impacts the subsequent patterning through a diffusive-reaction system of morphogens. The interplay between proliferation and patterning accurately captures experimentally observed variations in the shapes of growing mammary gland organoids in the presence of two types of FGF: WT and Stab. The integration of the model with laboratory data and its biological interpretation are presented in a complementary contribution.REFERENCES Okuda\, S.\, Inoue\, Y. & Adachi\, T. Three-dimensional vertex model for simulating multicellular morphogenesis. Biophysics and Physicobiology 12\, (2015) 13–20. doi:10.2142/biophysico.12.0_13 Gierer\, A. & Meinhardt\, H. A theory of biological pattern formation. Kybernetik 12\, (1972) 30–39. doi:10.1007/bf00289234Acknowledgement: Czech Science Foundation project no. GA23-04974S.\nhttps://indico.ijs.si/event/3289/
URL:https://web-f1.ijs.si/event/miroslav-vorechovsky-a-3d-vertex-model-for-mechanistic-coupling-of-patterning-and-proliferation-in-organoids/
LOCATION:Seminar room of physics (106) (IJS)
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