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X-ORIGINAL-URL:https://web-f1.ijs.si
X-WR-CALDESC:Events for Department of Theoretical Physics
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TZID:Europe/Ljubljana
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TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20230326T010000
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DTSTART:20231029T010000
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BEGIN:VEVENT
DTSTART;TZID=Europe/Ljubljana:20230710T140000
DTEND;TZID=Europe/Ljubljana:20230710T150000
DTSTAMP:20260425T142552
CREATED:20230628T114724Z
LAST-MODIFIED:20230710T123600Z
UID:10813-1688997600-1689001200@web-f1.ijs.si
SUMMARY:Arghyadip Mukherjee: "Topological interactions drive spindle orientation and the fate decision in the Drosophila embryo"
DESCRIPTION:During embryogenesis\, the earliest cell fate decision is tightly linked to nuclear positioning. Control of nuclear positioning arises from the integration of the different phases of activity during the cell cycle and associated cytoskeletal mechanics. Yet\, the mechanisms that ensure that the correct number of nuclei move to the appropriate place remain poorly understood. We discover that in the syncytial blastoderm of Drosophila embryos spindle orientation controls which nuclei migrate towards the cortex and which ones remain inside the embryo\, determining the eventual fate of the nuclei and the number of cells undergoing development. Using cytoskeletal mechanics and arguments describing the behaviour of space-filling systems\, we develop a minimal theory for aster-aster interactions in an aster aggregate. Combining theoretical predictions and computational methods inspired by integral geometry with mutations in cell cycle genes\, we show that spindle orientation is controlled by topological aster-aster interactions and is scale independent. Our work reveals general principles that underlie interplay between cytoskeletal mechanics with geometry and topology and how that uniquely affects density homeostasis and cell fate determination.\nhttps://indico.ijs.si/event/1700/
URL:https://web-f1.ijs.si/event/arghyadip-mukherjee-topological-interactions-drive-spindle-orientation-and-the-fate-decision-in-the-drosophila-embryo/
LOCATION:Z9/0-0 – F1 čajnica (Jamova)
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BEGIN:VEVENT
DTSTART;TZID=Europe/Ljubljana:20230720T140000
DTEND;TZID=Europe/Ljubljana:20230720T150000
DTSTAMP:20260425T142552
CREATED:20230628T114724Z
LAST-MODIFIED:20230720T095247Z
UID:10815-1689861600-1689865200@web-f1.ijs.si
SUMMARY:Emanuel Schneck: "Investigating Biomembrane Models at Fluid Interfaces—from Bacteria Surfaces to Glycolipid Domains to RNA delivery"
DESCRIPTION:Biological membranes based on lipid bilayers are major components of all living organisms\, but lipid layers are also used in many biomedical applications. We use biomembrane models in the form of lipid mono- and bilayers at water/air and water/oil interfaces in order to investigate various biological and biotechnologically relevant phenomena involving lipid layers. These experimental models are comprehensively characterized with numerous surface-sensitive techniques\, notably x-ray and neutron scattering/reflectometry and x-ray fluorescence\, as well as molecular dynamics simulations. The talk will cover examples from our recent activities\, including the conformation of wild-type bacterial lipopolysaccharide layers \, the formation of glycolipid-enriched ordered lipid domains \, the characteristics of lipid bilayers adsorbed to functionalized fluid interfaces \, and the pH-dependent charge and structural properties of transfection lipid layers for RNA delivery. S. Micciulla\, Y. Gerelli\, E. Schneck; Biophysical Journal\, 2019\, 116\, 1259. T. Mukhina\, G. Brezesinski\, C. Shen\, E. Schneck; J. Colloid Interf. Sci.\, 2022\, 615\, 786. J. Pusterla\, E. Scoppola\, C. Appel\, T. Mukhina\, C. Shen\, G. Brezesinski\, E. Schneck; Nanoscale 2022\, 14\, 15048.\nhttps://indico.ijs.si/event/1701/
URL:https://web-f1.ijs.si/event/emanuel-schneck-tba/
LOCATION:C/0-106 – Seminarska soba fizike (F5) (Jamova)
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