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[Biophysics seminar] Aljaž Godec: “From the kinetic Ising model to specific cell adhesion, and back”
29. March, 2022 at 13:00 - 14:00
| By exploiting a mapping onto a kinetic Ising-like model we will illuminate the many-body effects underlying the structure, formation, and dissolution of cellular adhesion domains in the presence and absence of external forces. We will present analytical results on the pair-correlation level for the complete thermodynamics and kinetics of adhesion clusters of any size, including the thermodynamic limit. A new kind of dynamical phase transition will be demonstrated: the mean formation and dissolution times per adhesion bond change discontinuously with respect to the bond-coupling parameter that in turn is controlled by the membrane rigidity. At the dynamical critical point, adhesion cluster formation and dissolution are the fastest, while the statistically dominant transition path undergoes a qualitative change. In the context of the classical Ising model the dynamical phase transition reflects a first order discontinuity in the magnetization-reversal time. Will will conclude by briefly discussing the relevance of these results for the mechanical regulation of cell adhesion, and argue that it is biologically favorable if cell adhesion is poised at criticality.
[1] K. Blom & A. Godec, Phys. Rev. X 11, 031067 (2021). |
| The meeting will take place online via Zoom:
Meeting ID: 833 0750 1179 Passcode: bio |