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[Biophysics seminar] Robert Vácha: “How Non-Enveloped Viruses Can Infect Cells”
10. May, 2022 at 13:00 - 14:00
| Non-enveloped RNA viruses are composed of a genome protected by a protein shell called a capsid. At the beginning of infection, these viruses get inside the cell and release their genome from the capsid, so the genome can start to be replicated, leading to the production of new copies of the virus. We developed a phenomenological model of an icosahedral virus capsid with a genome and used it to investigate how the virus can get inside the cell. We have shown that virus or virus-like nanoparticles with the right properties can enter the cell spontaneously, i.e., without ATP. Moreover, we demonstrated that the subsequent release of genome/cargo could occur via a rapid or slow pathway, which is mainly determined by the interaction range between capsid subunits. These findings could aid in the development of anti-viral drugs or assist in the design of virus-like nanoparticles for drug delivery. |
| The meeting will take place online via Zoom:
Meeting ID: 833 0750 1179 Passcode: bio |