Lipid nanoparticles (LNPs) are promising delivery tools for mRNAs vaccines due to their ability to protect and carry mRNA to target cells. However, designing effective LNPs for mRNA delivery systems remains a challenge due to a lack of understanding of structure–activity relationships onto the membranous surfaces, which are lipid dependent, among other environment conditions(ions and pH). Here we present the influence of the membrane composition on the adsorption and stability of the RNA molecules. Our extensive analysis points out key design rules for predicting the interaction of RNA and membrane surfaces and their implications on ensembles stability.
https://indico.ijs.si/event/1640/