Speakers: Miha Modic (National Institute of Chemistry)
Successful embryo implantation induces rapid morphological progression from rosette to lumen and then to gastrulation, which is closely coordinated with cell fate transition. By integrating machine learning, metabolic RNA sequencing, iCLIP, and proteomics of the protein-RNA interactome with embryology, I will present a blueprint for understanding how multilayered molecular networks coordinate developmental transitions. I will highlight three studies that demonstrate how cross-regulatory molecular logic ensures the robustness of developmental signalling pathways to rewire ribonucleoprotein assembly to drive cell fate transitions (Modic et al., 2023), important for the onset of gastrulation (Modic et al., 2019) and embryonic morphogenesis (Modic & van Genderen et al, in resubmission; Modic et al., Biorxiv 2021).
https://indico.ijs.si/event/1799/